Our Mission

The NSF-AIRFoundry is a National Science Foundation-funded BioFoundry that aims to transform how RNA is designed, synthesized and delivered so that we can democratize their use in all areas of biotechnology.

We will achieve our mission by integrating:

AI-augmented Design

AI-augmented design of RNA and lipid nanoparticles (LNPs) and precise production through automation and microfluidic engineering

State of the Art Facilities

An AI-augmented facility for state of the art instrumentation

Dedicated Ecosystem

An ecosystem for multidirectional learning, inclusion, and translation that includes both industry and academic partners

Research Focus Areas

The AIRFoundry has three working groups, each consisting of a Multidisciplinary Research Group and Technology Innovation Group.

RNA Design, Synthesis, Production and Purification

  • AI Optimization of RNA
  • Chemical Synthesis
  • Enzymatic Synthesis
  • In vivo and In vitro studies
  • Parallel production of RNA

Nanoparticle Delivery Vehicle Design, Testing, Production and Automation

  • Precision of Generation of Delivery Vehicles
  • Tissue-specific Extracellular Vesicles
  • High Throughput LNP formulation

AI research to augment human expertise

  • Task-driven search + recommendation
  • Learning from synthesized knowledge
  • Task Driven Interaction, open inquiry, understanding, and identification of hypothesis
  • Knowledge Sharing and Digital Twins

Our Partners

Childrens Hospital of Pennsylvania
University of Pennsylvania